Palmer did design the two powerful Greek Revival complexes, centered on temple-form chapels, of the Lane Presbyterian Theological Seminary, Walnut Hills (ca. 1830-1832), and the Western Baptist Theological Institute, Covington, Ky. (ca. 1840; engraved perspectives of both appear in Cist, 1841). In 1832 The Lane Seminary drew in both Dr. Lyman Beecher and the Rev. Calvin E Stowe as professors; Dr. Beecher brought with him Catherine E. Beecher and Harriet Beecher Stowe; both professors resigned in 1850. Both institutions were hotbeds of Abolitionism; the Baptist Seminary moved in the mid-1850s to Georgetown, Ky., where it remains as Georgetown College; Mrs. Stowe wrote Uncle Tom's Cabin, to a considerable extent based on experiences and accounts of slavery while in this area. And, of course, the sisters published The American Woman's Home: or, the Principles of Domestic Science (1869; published in Cincinnati as well as N.Y.), and other books that helped improve the situation of women—particularly single women—in the late 19th century. Most or all of Palmer's Lane Seminary buildings were replaced by McLaughlin's High Victorian Gothic structure(s) in the late 1870s, although the Beecher house remains on Gilbert Avenue as a center of Black history and the community. At least two residences, including the President's House of the W.B.T.I., remain in Covington, on 12th and Russell streets, in an historic neighborhood named for the Institute, which acquired a large farm and then subdivided it rapidly and profitably about 1840 in order to pay for its own facilities.

The handsome temple-form Lafayette and Franklin Bank on Third St. (1836) is credited to Palmer, but also to Henry Walter, and to Swiss/German-born John Jolasse, who apparently lived with and worked for Palmer, perhaps actually designing some of his best works. The U.S. Bank, formerly NWC Third and Main streets (before 1839), was a similar, but smaller and Ionic rather than Doric, temple. Another hexastyle Doric building on Third St., apparently originally a mansion, and later the Children's Home, might have been designed by Palmer. He designed, or at least superintended the construction, of the original St. Paul Roman Catholic Church in Pendleton; the upper part of its Greek tower was replaced by a Gothic spire in 1873, and the building was re-classicized by the Hannafords after a fire in 1899.

Painter notes that an essay in the 1829 Cincinnati city directory praises him as the architect of the Bazaar. But that in the street section Palmer is identified as a carpenter.

Palmer was still listed 1851-1852 (Knudson and Seneca Palmer were credited with the Bates Building in 1852); and Palmer & [Robert] Heines, 1853-1855.

Both taught architecture and mechanical drawing at St. Xavier College (now University, on Victory Parkway), then located on Sycamore between Sixth and Seventh streets. The first Roman Catholic church and educational institution within the city's limits, on this site, were gradually replaced by the Gothic Revival St. Xavier Church by the Pikets (1860) and Italianate/Second Empire Xavier College buildings; when the church burned in 1882, Louis Piket supplied a design for rebuilding the tower, but Samuel Hannaford received the commissioned (although the Pikets' original Gothic spire was far more suitable than the present domelet) and apparently designed later Xavier buildings on and around the church.

Anton Piket is said to have designed mid-19th-century buildings for the First Presbyterian Church, the Ohio Mechanics' Institute, and the Medical College.

Louis' other major works included (some phases of) the Grand Opera House, the Gibson Hotel, the city almshouse, the Guildhouse and renovation and a parish-hall addition to Trinity Church on Madison Ave near Third St. in Covington, Ky. (1886 and 1888), and the Hanke Bros. store on Main St. opposite 12th St. in Over-the-Rhine (1888); and for the same firm, three warehouses (1893). The Piket firm designed many other churches and schools, mostly for the Catholic communities of Cincinnati and N. Ky., including the highly visible Immaculata Church on Mt. Adams (1859-1860; possibly with design input by James W. McLaughlin) and Sacred Heart Church in Bellevue, Ky. (1892-1893; later covered with composition stone by the Hannafords), and also St. Paul Roman Catholic Church on W. Short St., Lexington, Ky.; as well as commercial and residential structures in Gothic Revival, Italianate, and Queen Anne styles.

Potter established his private practice in 1928 and joined Edgar D. Tyler and G. Marshall Martin beginning in 1933 in a partnership that continues today. Prior to the partnership, Mr. Tyler was Staff Architect for the Cincinnati Union Terminal Company and Mr. Martin was Chief Designer with a prominent Cincinnati architectural firm. In 1945, Mr. George Roth joined the partnership and in 1967, the firm's name was changed to George F. Roth and Partners. The firm is now known as The Roth Partnership.

Potter’s work included the Sigma Alpha Epsilon fraternity house (and possibly other commissions) at Miami University (1938) and projects for Ohio University in Athens and Oberlin College in Oberlin, Ohio. He was president of the Architects Society of Ohio and past vice president and secretary of the Cincinnati Chapter of the American Institute of Architects. He was also a member of the Ohio State Board of Examiners of Architects from 1948 to 1956. He was awarded a fellowship in the AIA in 1961.

Among the most notable commissions of Potter Tyler Martin & Roth are the Miami Inn in Oxford, alterations and additions to Shillito’s Department Store (1934), the Freshman Dormitory at Miami University (1935); Wyoming Elementary School (1935), Fine Arts Building at Miami University (1943); Liberty Street Firehouse (1938), the U. of Cincinnati Armory & Field House (1944), multiple dormitories at Ohio University (1954), Eden Park Band Pavilion (1958), Cincinnati Women's Club (1963), The John Weld Peck Building (1963, in partnership with Harry Hake & Partners), The Jewish Hospital (1963), and Cincinnati Art Museum Additions (1964)